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Universitätsklinikum Würzburg 

ZIM (Zentrum Innere Medizin)
Haus A3/A4 

Oberdürrbacherstr. 6

97080 Würzburg

ZOM / ZIM

Publikationen 2014

Heidrich B, Wiegand SB, Buggisch P, Hinrichsen H, Link R, Möller B, Böker KH, Teuber G, Klinker H, Zehnter E, Naumann U, Busch HW, Maasoumy B, Baum U, Hardtke S, Manns MP, Wedemeyer H, Petersen J, Cornberg M; HepNet Study Group

Treatment of naïve patients with chronic hepatitis C genotypes 2 and 3 with pegylated interferon alpha and ribavirin in a real world setting: relevance for the new era of DAA

PLoS One. 2014 Oct 10;9(10):e108751

Impact Factor: 3.702

 

Lynfield R, Davey R, Dwyer DE, Losso MH, Wentworth D, Cozzi-Lepri A, Herman-Lamin K, Cholewinska G, David D, Kuetter S, Ternesgen Z, Uyeki TM, Lane HC, Lundgren J, Neaton JD; INSIGHT Influenza Study Group

Outcomes of influenza A(H1N1)pdm09 virus infection: results from two international cohort studies

PLoS One. 2014 Jul 8; 9(7):e101785

Impact Factor: 3.702

 

Nordell AD, McKenna M, Borges ÁH, Duprez D, Neuhaus J, Neaton JD; INSIGHT SMART, ESPRIT Study Groups; SILCAAT Scientific Committee

Severity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation

J Am Heart Assoc. 2014 May 28; 3(3):e000844

Impact Factor: 4.318

 

Wiebecke S, Schulze P, Heinz WJ, Klinker H

HIV infection: high standard of treatment, new goals

Dtsch Med Wochenschr. 2014 Jun; 139(23):1216-9

 

Borges AH, O'Connor JL, Phillips AN, Baker JV, Vjecha MJ, Losso MH, Klinker H, Lopardo G, Williams I, Lundgren JD; INSIGHT SMART Study Group; ESPRIT Study Group; SILCAAT Scientific Committee

Factors associated with D-dimer levels in HIV-infected individuals

PLoS One. 2014 Mar 13; 9(3):e90978

Impact Factor: 3.702

 

Grammatikos G, Lange C, Susser S, Schwendy S, Dikopoulos N, Buggisch P, Encke J, Teuber G, Goeser T, Thimme R, 

Klinker H, Boecher WO, Schulte-Frohlinde E, Penna-Martinez M, Badenhoop K, Zeuzem S, Berg T, Sarrazin C

Vitamin D levels vary during antiviral treatment but are unable to predict treatment outcome in HCV genotype 1 infected patients.

PLoS One. 2014 Feb 7; 9(2):e87974

Impact Factor: 3.702

 

von Bibra M, Rosenkranz B, Pretorius E, Rabie H, Edson C, Lenker U, Cotton M, Klinker H

Are lopinavir and efavirenz serum concentrations in HIV-infected children in the therapeutic range in clinical practice?

Paediatr Int Child Health. 2014 May; 34(2):138-41

Impact Factor: 0.982

 

M. Rau, Schmitt J., Kudlich T., Martin J.J.G., Rodriguez Romero M., Klinker H., Tony H.P., Müllhaupt B., Geier A.

Higher frequency of peripheral CD3CXCR3 and CD4CXCR3 positive blood cells in HCV patients in context of bile acid retention

30. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, 24.- 25.1.2014, Tübingen, Abstract P5.21, Z Gastroenterol 2014; 52: 122-123

 

H. Wedemeyer, Mauss S., Busch H. W., Umgelter A., Buggisch P., Klinker H., Hüppe D., Hill A., Lonjon-Domanec I., Zeuzem S.

Efficacy and safety of Telaprevir in patients with hepatitis C genotype 1 infection: The German Telaprevir early access program

30. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, 24.- 25.1.2014, Tübingen, Abstract P2.05, Z Gastroenterol 2014; 52: 80-81

 

M. Harris, L.E. Taylor, M. Hernandez, H. Klinker, E. Kaufman, Z. Jalali, S. Marcus, R. Fox, M. Badshah, N. Bräu, Liver Cancer in HIV Study Group

Impact of Screening on Survival of Hepatocellular Carcinoma (HCC) in HIV/HBV-Coinfected Patients

CROI 2014, 3.-6.3.2014, Boston,MA, Abstract

 

C. Kasang, S. Kalluvya, C. Majinge, G. Kongola, M. Mlewa, I. Massawe, R. Kabyemera, K. Magambo, H. Klinker, E. Koutsilieri, W. Preiser, D. Hofmann, J. Hain, A. Müller, B., Weissbrich, A. Ulmer, A. Rethwilm, A. Stich, C. Scheller

Effects of prednisolone on CD4 counts and HIV disease progression: a two-year clinical trial

CROI 2014, 3.-6.3.2014, Boston,MA, Abstract 336

 

N. Merchante, B. Minguez, C. Tural, L. Kikuchi, F. Rodrifuez-Arrondo, T.-Y. Chen, M. Ventura, M. Harris, J. Daruich, D. E. Kaplan, E.Merino, M. F. Silva, J. Rockstroh, J.Muňoz, F. Jover, H. Klinker, M. Delgado-Fernandez,, S. marcus, J. Aberg, J. A. Pinedfa, M. Sherman, Y. Hoshida, J. Marrero, N. Bräu, Liver Cancer in HIV Study Group

Predicting survival of HIV-infected patients with liver cancer – the SHILCA score and staging model

49th Annual Meeting of the European Association for the Study of the Liver (EASL), London, 9.-13.4.2014, Abstract/Vortrag O35, J Hepatol 2014; 60 (Suppl 1): S15

 

A. Aytaman, R. K. Fox, M. Núñez, M. K. Jain, E. Vispo, L. Kikuchi, E. Page, L. E. Taylor, B. Mínguez, M. Ventura, N. Merchante, D. E. Kaplan, M. Harris, H. Klinker, M. D. Hernández, K. K. Hunt, J. A. Pineda, M. Nelson, P. Barreiro, N. Bräu,  Liver Cancer in HIV Study Group

Impact of Screening on Staging and Survival of Hepatocellular Carcinoma (HCC) in HIV/HBV-Coinfected Patients

49th Annual Meeting of the European Association for the Study of the Liver (EASL), London, 9.-13.4.2014, Abstract P558, J Hepatol 2014; 60 (Suppl 1): S255

 

M. Ventura, M. B. Badshah, M. Harris, N. Merchante, T. Y. Chen, N. Qazi, E. Vispo, H. Tossonian, H. Klinker, K. Marks, E. Page, B. Conway, L. E. Taylor, J. Rockstroh, M. K. Jain, M. Nelson, P. Barreiro, J. A. Pineda, M.  Sherman, B. Mínguez, N. Bräu, Liver Cancer in HIV Study Group

Continental Differences among HIV-Infected Patients with Hepatocellular Carcinoma: Europe vs. North America

49th Annual Meeting of the European Association for the Study of the Liver (EASL), London, 9.-13.4.2014, Abstract P559, J Hepatol 2014; 60 (Suppl 1): S255

 

J. Fischer, S. Böhm, D. Deichsel, V. Knop, H. Klinker, B. Möller, J. Rasenack, H. Hinrichsen, U. Spengler, P. Buggisch, C. Sarrazin, T. Berg

Association of a genetic variant of the mitochondrial antiviral signaling protein (MAVS)  with interferon response in chronic hepatitis C virus infection

49th Annual Meeting of the European Association for the Study of the Liver (EASL), London, 9.-13.4.2014, Abstract P747, J Hepatol 2014; 60 (Suppl 1): S320

 

B. Heidrich, S. B. Wiegand, J. Petersen, H. Hinrichsen, R. Link, B. Moeller, K. H. Boeker, G. Teuber, H. Klinker, E. Zehnter, U. Naumann, H. W. Busch, U. Jacobi, M. P. Manns, H. Wedemeyer, M. Cornberg for HepNet Study Group

Overtreatment of patients with chronic hepatitis C (CHC) gehotype 2/3 with low baseline viral load and RVR: experiences in a real world setting

49th Annual Meeting of the European Association for the Study of the Liver (EASL), London, 9.-13.4.2014, Abstract P1109, J Hepatol 2014; 60 (Suppl 1): S447

 

M. Harris, L. E. Taylor, M. Hernandez, H. Tossonian, H. Klinker, E. Kaufman, Z. Jalali, M. Badshah, B. Conway, R. Fox, M. Sherman, N. Bräu, Liver Cancer in HIV Study Group

Impact of Screening on Staging and Survival of Hepatocellular Carcinoma (HCC) in HIV / HBV-Coinfected Patients

The 23rd Annual Canadian Conference On HIV/AIDS Research 2014 (CAHR), St. John’s, New Foundland-Labrador, 1 – 4 May 2014, Abstract No. P054

 

W. J. Heinz, D. Kuschak, D. Schirmer, D. Keller, H. Klinker

HPLC-Methodik zur Bestimmung von S- und R-Telaprevir bei Patienten in der Therapie der Hepatitis C

12. Kongress für Infektionskrankheiten und Tropenmedizin, 25.-28.6.2014, Köln, Abstract/Poster P-003

 

A. Oberhagemann, S. Kalluvya, U. Lenker, D. Keller, H. Klinker

Therapeutisches Drug Monitoring (TDM) antiretroviraler Medikamente in einer HIV-Ambulanz in Tansania

12. Kongress für Infektionskrankheiten und Tropenmedizin, 25.-28.6.2014, Köln, Abstract/Poster P-030

 

W. J. Heinz, S. Wiebecke, P. Schulze, D. Kuschak, A. Elter, D. Keller, H. Klinker

Raltegravir-Konzentrationen in der klinischen Praxis der HIV Therapie

12. Kongress für Infektionskrankheiten und Tropenmedizin, 25.-28.6.2014, Köln, Abstract/Poster P-032

 

H. Klinker, S. Usadel, W. Heinz, W.V. Kern

Zweimaliger Suizidversuch mit Nevirapin, Tenofovir und Emtricitabin - klinischer Verlauf und Drug Monitoring

12. Kongress für Infektionskrankheiten und Tropenmedizin, 25.-28.6.2014, Köln, Abstract/Poster P-046

 

P. Schulze, T. Löwe, I. Klein, C. Lapa, H. Neubauer, K. Brehm, E. Hartmann, H. Klinker

Atypische alveoläre Echinokokkose

12. Kongress für Infektionskrankheiten und Tropenmedizin, 25.-28.6.2014, Köln, Abstract/Poster P-084

 

H. Klinker

Der HIV-Patient in der ärztlichen Praxis

Pharmakon 2014: 2: 319-326

 

K. Kunisaki, D. Niewoehner, G. Collins, D. Nixon, E. Tedaldi, C. Akolo, C. Kityo, H. Klinker, A. la Rosa, J. Connett, INSIGHT START Study Team

Chronic obstructive pulmonary disease (COPD) in a large international cohort of HIV-infected adults with CD4+ counts >500 cells/mm3

International AIDS Conference, Melbourne, Australia, 20-25 July 2014, oral abstract session  “Beyond Control of HIV: Co-morbidities and Co-infections around the world” Abstract number A-641-0114-00760

 

W. J. Heinz, R. Handgretinger, H. Klinker, M. Döring

Posaconazole (PSC) concentration in children receiving antifungal prophylaxis after allogenic haematopoetic stem cell transplantation (HSCT)

54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC, US, 5.-9.9.2014, Poster A-722

 

J. Fischer, S. Böhm, D. Deichsel, V. Knop, H. Klinker, B. Möller, J. Rasenack, H. Hinrichsen, U. Spengler, P. Buggisch, C. Sarrazin, T. Berg

Einfluss von genetischen Varianten des mitochondrialen antiviralen Signalproteins (MAVS) auf den Behandlungserfolg einer interferonbasierten Therapie

69. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten, 17.-20.09.2014, Leipzig, KG 071, Z Gastroenterol 2014; 52: 879

 

W. Heinz, R.Handgretinger, H. Klinker, M. Döring

Posaconazole (PSC) Concentration in Children Receiving Antifungal Prophylaxis after Allogeneic Haematopoetic Stem Cell Transplantation (HSCT)

54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 5.-9.9.2014, Washington, DC, Poster A-722

 

M. Rau, J. Schmitt, T. Kudlich, J. J. G. Martin, M. J. Monte, H. Klinker, H. P. Tony, B. Müllhaupt, A. Geier

Higher frequency of peripheral CD 3CXCR3 and CD 4CXCR3 positive blood cells in HCV patients in context of bile acid retention

42. Jahrestagung der Gesellschaft für Gastroenterologie in Bayern, 23.-24.10.2014, Augsburg, K 16, Z Gastroenterol 2014; 52: 1104

 

J. Zirkel, H. Klinker, A. Kuhn, J. Elias, D. Thurnwald, H. Einsele, W.J. Heinz

Epidemiologie der Candidämie bei hämatologischen und onkologischen Patienten während einer 10 jährigen Untersuchungsphase.

Jahrestagung 2014 der Deutschen Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO) 10.-14.10.2014, Hamburg, P504

 

Maertens J, Cornely OA, Ullmann AJ, Heinz WJ, Krishna G, Patino H, Caceres M, Kartsonis N, Waskin H, Robertson MN

Phase 1B study of the pharmacokinetics and safety of posaconazole intravenous solution in patients at risk for invasive fungal disease

Antimicrob Agents Chemother 2014; 58: 3610-3617

Impact Factor: 4.540

 

Nucci M, Marr KA, Vehreschild MJ, De Souza CA, Velasco E, Cappellano P, Carlesse F, Queiroz-Telles F, Sheppard DC, Kindo A, Cesaro S, Hamerschlak N, Solza C, Heinz WJ, Schaller M, Atalla A, Arikan-Akdagli S, Bertz H, Galvao Castro C, Herbrecht R, Hoenigl M, Harter G, Hermansen NE, Josting A, Pagano L, Salles MJ, Mossad SB, Ogunc D, Pasqualotto AC, Araujo V, Troke PF, Lortholary O, Cornely OA, Anaissie E

Improvement in the outcome of invasive fusariosis in the last decade   

Clin Microbiol Infect 2014; 20: 580-585

Impact Factor: 5.059

 

Heimann SM, Vehreschild MJ, Meintker L, Heinz W, Schroeder T, Von Bergwelt-Baildon M, Cornely OA, Vehreschild JJ 

Different doses of micafungin for prophylaxis of invasive fungal diseases in hemato-oncological high-risk patients: a web-based non-interventional trial in four large university hospitals in Germany

Transpl Infect Dis 2014; 16: 968-974

Impact Factor: 2.043

 

Rau M, Heinz W Ullmann, AJ

Patient with COPD after allogeneic hematopoietic stem cell transplantation with cough and subfebrile temperature

Dtsch Med Wochenschr 2014; 139: 2239-2241

 

Schwab KS, Hahn-Ast  C, Heinz WJ, Germing U, Egerer G, Glasmacher A, Leyendecker C, Marklein G, Nellessen CM, Brossart P, Von Lilienfeld-Toal M

Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case documentation in four university hospitals

Infection 2014; 42: 97-104

Impact Factor: 2.449

 

Zirkel J, Grau A, Elias J, Heinz WJ

Influence of fluconazole prophylaxis on epidemiology and outcome of candidemia in a German clinical center for hematology and oncology

Frühjahrstagung der Sektion Antmykotische Chemotherapie der PEG, Bonn 23.-24.5.2014

 

B. Spiess, M. Reinwald, P. Postina, J. J. Vehreschild, C. P. Heußel, W. Heinz, T. Boch, W. K. Hofmann, D. Buchheidt

Investigating Aspergillus PCR-negative Tissue Biopsy Samples from immunocompromised Patients using DNA Microarray Technology improves Diagnosis of Invasive Fungal Infections (IFI)

54st ICAAC, Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington 10-13.9.2013, M-1085

 

K. Marr, E. Bow, W. Heinz, M. Lee, R. Maher, B. Zeiher, J. Maertens

A Phase 3 Randomized, Double-Blind, Non-Inferiority Trial Evaluating Isavuconazole (ISA) Vs. Voriconazole (VRC) for the Primary Treatment of Invasive Mold Infection (SECURE): Outcomes in Subset of Patients with Hematologic Malignancies (HM

54st ICAAC, Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington 10-13.9.2013, M-1757

 

M. Reinwald, B. Spiess, W. Heinz, J. J. Vehreschild, J. Hahn, S. W. Krause, T. Boch, W-K. Hofmann, D. Buchheidt

Aspergillus Specific PCR of Specimens more Adequately Representing the Infectious Localization such as Bronchoalveolar Lavage, Cerebrospinal Fluid or Tissue/Effusion Samples are Superior to Testing Concurrent Blood Samples in Immunocompromised Patients with Suspected Invasive Aspergillosis

54st ICAAC, Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington 10-13.9.2013, M-1772

 

Reinwald, M, Spiess B., Heinz W.J., Cornely O.A., Schwerdtfeger R., Hahn J., Krause S.W., Bertz H., Reuter S., Wolf H.H., Claus B., Boch T., Hofmann W.-K., Buchheidt D

Die Aspergillus spezifische PCR-Diagnostik aus klinischen Proben beteiligter Organe bei einer Aspergillus-Infektion immunsupprimierter Patienten ist der Diagnostik aus Blutproben überlegen

Jahrestagung der deutschen, österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie, Hamburg 10-14.10.2014, V298

 

Spiess, Birgit, Reinwald M., Postina P., Cornely O.A., Heußel C.-P., Heinz W., Lehrnbecher T., Bertz H., Hahn J., Janßen G., Claus B., Lauten M., Egerer G., Behrends U., Nathrath M., Wolf H.-H., Gruhn B., Frickhofen N., Woessmann W., Will S., Merker N., Boch T., Hofmann W.-K., Buchheidt D

Der Nachweis von DNA fungaler Pathogene in Aspergillus-PCR-negativen Gewebeproben von immunsupprimierten hämatologischen Patienten verbessert die Diagnostik invasiver Pilzinfektionen

Jahrestagung der deutschen, österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie, Hamburg 10-14.10.2014, V299

 

W. J Heinz, O. A. Cornely, B. Franks, F. Shi, N. Azie, J. Maertens

A Phase III, Randomized, Double-Blind Trial to Evaluate Efficacy and Safety of Isavuconazole versus Voriconazole in Patients with Invasive Mold Disease (SECURE): Outcomes in Hematopoietic Stem Cell Transplant Patients with Invasive Aspergillosis

56th ASH (American Society of Hematology) Annual Meeting, 6-9.12.2014 San Francisco, USA, #1133