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ZOM / ZIM

Ansprechpartner:
Prof. Dr. rer. nat. Jürgen Löffler
loeffler_j@ukw.de

Kontakt:

Bürotel.: 0931/201-36412
Fax: 0931/201-36409

Labortel.: 0931/201-36404
Labortel.: 0931/201-36408

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Josef-Schneider-Strasse 2
97080 Würzburg
Haus C11, Erdgeschoß

Publikationen

Wissenschaftliche Originalarbeiten

  • Teutschbein J., Simon S., Lother J., Springer J., Hortschansky P., Morton O., Löffler J., Einsele H., Conneally E., Rogers T., Guthke R., Brakhage A., Kniemeyer O. “Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis”, 2016, Journal of Proteome Research, in press
  • Dix A., Czakai K., Springer J., Fliesser M., Bonin M., Guthke R., Schmitt A., Einsele H., Linde J., Löffler J. “Genome-wide Expression Profiling Reveals S100B as Biomarker for Invasive Aspergillosis”, 2016, Frontiers in Microbiology, in press
  • Fliesser M., Wallstein M., Kurzai O., Einsele H., Loeffler J. “Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells", 2016, Mycoses, in press
  • White L., Wiederhold N., Loeffler J., Najvar L., Melchers W., Herrera M., Bretagne S., Wickes B., Kirkpatrick W., Barnes R., Donnelly P., Patterson T. “A comparison of the non-culture blood-based tests for diagnosing invasive aspergillosis in an animal model”, 2016, Journal of Clinical Microbiology, in press
  • Springer J., Goldenberger D., Schmidt F., Weisser M., Wehrle-Wieland E., Einsele H., Frei R., Loeffler J. “Development and application of two independent real-time PCR assays to detect clinically relevant Mucorales species”, 2016, Journal of Medical Microbiology, in press
  • Springer J., White L., Hamilton S., Michel D., Barnes R., Einsele H., Löffler J. “A comparison of the performance of Aspergillus PCR when testing a range of blood based samples in accordance with international methodological recommendations”, 2016, Journal of Clinical Microbiology, in press
  • Lupianez C., Canet L., Carvalho A., Alcazar-Fuoli C., Springer J., Lackner M., Segura-Catena J., Comino A., Olmedo C., Rios R., Fernández-Montoya A., Cuenca-Estrella M., Solano C., Lopez-Nevot M., Cunha C., Oliveira-Coelho A.,  Villaescusa C., Fianchi L., Aguado J., Pagano L., Lopez-Fernandez L., Potenza L., Luppi M., Lass-Flörl C., Löffler J., Einsele H., Vázquez L., Study Group PCRAGA, Jurado M., Sainz J. “Polymorphisms in host immunity modulating genes and risk of invasive aspergillosis: Results from the aspBIOmics consortium”, 2015, Infection and Immunity, in press
  • Irmer H., Tarazona S., Sasse C., Olbermann P., Loeffler J., Krappmann S., Conesa A., Braus G. „RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior”, 2015, BMC Genomics, 16: 640-665
  • Springer J., Lackner M., Nachbaur D.,  Girschikofsky M., Risslegger B., Mutschlechner W.,  Fritz J.,  Heinz W., Einsele H., Ullmann A., Loeffler J., Lass-Florl C., “Prospective multicenter PCR-based Aspergillus DNA screening in high risk patients with and without primary antifungal mold prophylaxis”, 2015, Clinical Microbiology and Infection, in press
  • Cruciani M., Mengoli C., Loeffler J., Donnelly P., Barnes R., Jones B., Klingspor L., Morton O., Maertens J. “Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people”, 2015, Cochrane Database of Systematic Reviews, Issue 9. Art. No.: CD009551
  • Fliesser M., Morton O., Bonin M., Ebel F., Hünniger K., Kurzai O., Einsele H.,  Löffler J. „Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells”, 2015, International Journal of Medical Microbiology
  • Beitzen-Heineke A., Bouzani M., Schmitt A., Kurzai O., Huenniger K., Einsele H., Loeffler J. „Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus fumigatus infection“, 2015 Medical Mycology
  • White L., Barnes R., Springer J., Klingspor L., Cuenca-Estrella M., Morton O., Lagrou K., Bretagne S., Melchers W., Mengoli C., Donnelly P., Heinz W., Loeffler J. and the EAPCRI. “The clinical performance of Aspergillus PCR when testing serum and plasma- a study by the European Aspergillus PCR Initiative”, 2015, Journal of Clinical Microbiology
  • Loeffler J., Mengoli C., Springer J., Bretagne S., Cuenca Estrella M., Klingspor L., Lagrou K., Melchers W., Morton O., Barnes R., Donnelly P., White L., on behalf of the European Aspergillus PCR Initiative. “Analytical comparison of in vitro spiked human serum and plasma for the PCR-based detection of Aspergillus fumigatus DNA – a study by the European Aspergillus PCR Initiative”, 2015, Journal of Clinical Microbiology
  • White L., Wingard J., Bretagne S., Loeffler J., Patterson T., Slavin M., Barnes R., Pappas P., Donnelly P. "Aspergillus PCR: a systematic review of evidence for clinical use in comparison with antigen testing", 2015, Clinical Infectious Diseases
  • Paholcsek M., Fidler G., Kónya J., Rejto L., Méhes G., Bukta E., Loeffler J., Biró S. “Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia”, 2015, BMC Infectious Diseases
  • Einsele H., Löffler J., Kapp M., Rasche L., Mielke S., Grigoleit U. „Immunotherapy for viral and fungal infections“. 2015, Bone Marrow Transplantation
  • Löffler C., Löffler J., Kobsar A., Speer S., Eigenthaler M. „Septic versus colonizing Group B Streptococci differentially regulate inflammation and apoptosis in human coronary artery endothelial cells – a pilot study”. 2015, Journal of Pediatrics and Neonatal Care
  • Mueller-Leisse J., Brueggemann S., Bouzani M., Schmitt A., Einsele H., Loeffler J. “Polymorphonuclear Neutrophils and Granulocytic Myeloid-Derived Suppressor Cells Inhibit Natural Killer Cell Activity Towards Aspergillus fumigatus”, 2015, Medical Mycology
  • Rambach G., Blum G., Latge J., Fontaine T., Heinekamp T., Hagleitner M., Jeckström H., Weigel G., Würtinger P., Pfaller K., Krappmann S., Löffler J., Lass-Floerl C., Speth C. „Identification of Aspergillus fumigatus surface components that mediate  interaction of conidia and hyphae with human platelets”. 2015, Journal of Infectious Diseases
  • Leonhardt I., Spielberg S., Weber M., Albrecht-Eckardt D., Bläss M., Claus R., Barz D., Löffler J., Hünniger K., Kurzai O. “The fungal Quorum-Sensing-Molecule Farnesol activates innate immune cells but suppresses cellular adaptive immunity", 2015, MBio
  • Loeffler C., Kapp M., Grigoleit U., Mielke S., Loeffler J., Heuschmann P., Malzahn U., HuppE., Einsele H., Stuhler G. “Control of relapsed or refractory acute myeloid leukemia by clofarabine in preparation for allogeneic stem cell transplantation”. 2015, Leukemia and Lymphoma
  • Rieber N., Singh A., Carevic M., Öz H., Bouzani M., Amich J., Ost M., ye, Z., Schäfer I., Mezger M., Klimosch S., Weber A., Handgretinger R., Liese J., Engeholm M., Schüle R., Salih H., Marodi L., Speckmann C., Grimbacher B., Ruland J., Brown G., Beilhack A., Loeffler J., Hartl D. “Pathogenic fungi regulate T-cell immunity by including neutrophil myeloid-derived suppressor cells through a dectin-1 / CARD9 and ROS-mediated mechanisms”. 2015, Cell Host and Microbe
  • Hünniger K., Bieber K., Martin R., Lehnert T., Figge T., Löffler J., Guo R., Riedemann N., Kurzai O. „A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a“. 2014, Journal of Immunology
  • Cunha C., Kurzai O., Löffler J., Aversa F., Romani L., Carvalho A. “Neutrophil responses to Aspergillosis: New roles for old players”. 2014, Mycopathologia 178: 387-393
  • Lother J., Breitschopf T., Krappmann S., Morton O., Bouzani M., Kurzai O., Gunzer M., Hasenberg M., Einsele H., Loeffler J. „Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus“. 2014, International Journal of Medical Microbiology
  • Cunha C., Aversa F., Lacerda J., Busca A., Kurzai O., Grube M., Löffler J., Maertens J., Bell A., Inforzato A., Barbati E., Almeida B., Santos e Sousa P., Barbui A., Potenza L., Caira M., Rodrigues F., Salvatori G., Pagano L., Luppi M., Mantovani A., Velardi A., Romani L., Carvalho A. “Genetic PTX3 deficiency and aspergillosis in stem cell transplantation”. 2014, New England Journal of Medicine 370: 421-432
  • Semmlinger A. Fliesser M., Waaga.Gasser A. Dragan M., Morton O., Einsele H., Loeffler J. „Fever-range temperature modulates activation and function of human dendritic cells stimulated with the pathogenic mould Aspergillus fumigatus”. 2014, Medical Mycology
  • Morton O., Fliesser M., Dittrich M., Mueller T., Bauer R., Kneitz S., Hope W., Rogers T., Einsele H., Loeffler J. „Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelial/endothelial interface”. 2014, PLOS One 9e98279
  • Das Gupta M., Fliesser M., Springer J., Breitschopf T., Schlossnagel H., Schmitt A., Kurzai O., Hünniger K., Einsele H., Löffler J. „Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells“. 2014, International Journal of Medical Microbiology, in press
  • Voigt J., Huenniger K., Bouzani M., Jacobsen I., Barz D., Hube B., Löffler J., Kurzai O. “Human NK cells act as phagocytes against Candida albicans and mount an inflammatory response which modulates neutrophil antifungal activity”. 2014, Journal of Infectious Diseases, 209(4):616-26.
  • Rogers T., Morton O., Springer J., Conneally E., Heinz W., Kenny C., Frost S., Einsele H., Loeffler J. “Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies” 2013, British Journal of Haematology, 161(4):517-24.
  • Mueller-Loebnitz C., Ostermann H., Franzke A., Loeffler J., Uharek L., Topp M., Einsele H. „Immunological aspects of Candida and Aspergillus systemic fungal infections“. 2013, Interdisciplinary Perspectives on Infectious Diseases, 2013:102934
  • Springer J., Morton O., Perry M., Heinz W., Paholcsek M., Alzheimer M., Rogers T., Barnes R., Einsele H., Loeffler J., White L. “Comparison of serum and whole blood specimens for the detection of Aspergillus DNA in high-risk haematological patients: A multicenter evaluation”. 2013, Journal of Clinical Microbiology, 51(5):1445-50
  • Tan S.M., Kapp M., Flechsig C., Kapp K., Rachor J., Eyrich M., Loeffler J., Einsele H., Grigoleit U. “Stimulating surface molecules, Th1-polarizing cytokines, proven trafficking-a new protocol for the generation of clinical-grade dendritic cells”. 2013, Cytotherapy, 15(4):492-506
  • Lyon G., Abdul-Ali D., Loeffler J., White L., Wickes B,, Herrera M., Alexander B., Baden L., Clancy C., Denning D., Hong Ngyuen M., Sugrue M., Wheat J., Wingrad J., Donnelly P., Barnes R., Patterson T., Caliendo A. “Development and evaluation of a calibrator material for nucleic acid based assays for diagnosing aspergillosis”. 2013, Journal of Clinical Microbiology 51: 2403-2405
  • Grube M., Loeffler J., Mezger M., Krüger B., Echtenacher B., Hoffmann P., Edinger M., Einsele H., Andreesesn R., Holler E. „TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation“. 2013, Medical Mycology, 51(8):818-25
  • Maschmeyer G., Heinz W., Hertenstein B., Horst A., Requadt C., Wagner T., Cornely O., Loeffler J., Ruhnke M. „Immediate versus deferred empirical antifungal (IDEA) therapy in high-risk aptients with febrile neutropenia: a randomized, double-blind, placebo-controlled multicentre study“. 2013, European Journal of Clinical Microbiology and Infectious Diseases, 32(5):679-89
  • Bouzani M., Einsele H., Loeffler J. „Functional analysis is a paramount prerequisite for understanding the in vitro interaction of human Natural Killer cells with Aspergillus fumigatus“. 2012, Journal of Infectious Diseases, 205(6):1025-6; author reply 1026-7
  • Springer J., Einsele H., Loeffler J. „Molecular techniques in the diagnosis of deep and systemic mycoses“. 2012, Clinics in Dermatology, 30(6):651-6
  • Donat S., Hasenberg M., Schäfer T., Ohlsen K., Gunzer M., Einsele H., Loeffler J., Beilhack A., Krappmann S. „Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis“. 2012, Virulence, 3(1):51-61
  • Springer J., Schloßnagel H., Heinz W., Doedt T., Soeller R., Einsele H., Loeffler J., „A novel method combining plasma with a whole blood fraction shows excellent sensitivity and reproducibility for patients at high risk for invasive aspergillosis”. 2012, Journal of Clinical Microbiology 50: 2585-2591
  • Reichard U., Buchheidt D., Lass-Flörl C., Loeffler J., Lugert R., Ruhnke M., Tintelnot K., Weig M., Groß U. „Interlaboratory comparison of PCR-based identification of Candida and Aspergillus DNA in spiked blood samples“. 2012, Mycoses 55: 426-434
  • Morton O., Bouzani M., Loeffler J., Rogers T. “Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity. 2012, Frontiers in Microbiology 3:413
  • Springer J., Loeffler J., Heinz W., Schlossnagel H., Lehmann M., Morton O., Rogers T., Schmitt C., Frosch M., Einsele H., Kurzai O. „Pathogen specific DNA enrichment does not increase sensitivity of PCR for diagnosis of invasive aspergillosis in neutropenic patients”. 2011, Journal of Clinical Microbiology, 49: 1267-1273
  • Flechsig C., Suezer Y., Kapp M., Tan S., Loeffler J., Sutter G., Einsele H., Grigoleit G.U. “Uptake of antigens from modified vaccinia Ankara virus-infected leukocytes enhances the immunostimulatory capacity of dendritic cells”. 2011, Cytotherapy, 13(6):739-52
  • Kapp M., Schargus M., Deuchert T., Springer J., Wendel F., Loeffler J., Grigoleit G., Kurzai O., Heinz W., Einsele H., Stuhler G. „Endophthalmitis as a primary clinical manifestation of fatal fusariosis in an allogeneic stem cell transplant recipient“. 2011, Transplantation Infectious Diseases 13: 374-379
  • Loeffler J., Barnes R., Donnelly P. “Standardization of Aspergillus PCR diagnosis”. 2011, Bone Marrow Transplantation, 47(2):299-300
  • Morton O., Varga J., Hornbach A., Mezger M., Sennefelder H., Kneitz S., Kurzai O., Krappmann S., Einsele H., Nierman W., Rogers T., Loeffler J. “The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. 2011, PLoS ONE, 6: e16016
  • Beyrich C., Loeffler J., Kobsar A., Speer C., Kneitz S., Eigenthaler M. “Infection of human coronary artery endothelial cells by group B Streptococcus contributes to dysregulation of apoptosis, hemostasis and innate immune responses”. 2011, Mediators of Inflammation, doi:10.1155/2011/971502
  • Staab A., Fleischer M., Loeffler J., Said H., Katzer A., Plathow C., Einsele H., Flentje M., Vordermark D. “Small interfering RNA targeting HIF-1alpha reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro”. 2011, Strahlentherapie und Onkologie, 187: 252-259
  • Stuehler C., Khanna N., Bozza S., Zelante T., Moretti S., Kruhm M., Lurati S., Conrad B., Worschech E., Stevanovic S., Krappmann S., Einsele H., Latgé J.P., Loeffler J., Romani L., Topp M. “Cross-protective Th1 immunity against Aspergillus fumigatus and Candida albicans”. 2011, Blood, 117(22):5881-91
  • Morton O., Clemons K., Springer J., Mueller J., Rogers T., Stevens D., Kurzai O., Einsele H., Loeffler J. “Real-time PCR and quantitative culture for monitoring experimental Aspergillus fumigatus intracranial infection in neutropenic mice”. 2011. Journal of Medical Microbiology, 60: 913-919
  • Bouzani M., Ok M., McCormick A., Ebel F., Kurzai O., Morton O., Einsele H., Loeffler J. “Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by Interferon gamma release”. 2011, Journal of Immunology, 187(3):1369-76
  • Bauer R., Mezger M., Blockhaus C., Schmitt AL., Kurzai O., Einsele, H., Loeffler J. „40-O-[2-Hydroxyethhly] modulates human dendritic cell function during exposure to Aspergillus fumigatus“. 2011, Journal of Basic Microbiology, 52(3):269-76
  • White L., Mengoli C., Bretagne S., Cuenca Estrella M., Finnstrom N., Klingspor L., Melchers W., McCulloch E., Barnes R., Donnelly P., Loeffler J., on behalf of the European Aspergillus PCR Initiative. „An evaluation of Aspergillus PCR protocols for testing serum specimens“. 2011. Journal of Clinical Microbiology, 49(11):3842-8
  • Ok M., Einsele H., Loeffler J. „Genetic susceptibility to Aspergillus fumigatus infections“ 2011,. International Journal of Medical Microbiology 301: 445-452
  • Spinnler K., Mezger M., Steffens M., Senefelder H., Kurzai O., Einsele H., Loeffler J. “Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus”. 2010, Medical Mycology, 48(4):589-97
  • White L., Bretagne S., Klingspor L., Melchers W., Mc Culloch E., Schulz B., Finnstrom N., Mengoli C., Barnes R., Donnelly P., Loeffler J. on behalf of the European Aspergillus PCR initiative. “Aspergillus PCR: One step closer to standardization”. 2010, Journal of Clinical Microbiology, 48(4):1231-40
  • Kurzwelly D., Knop S., Guenther M., Loeffler J., Korfel A., Thiel E., Hebart H., Simon M., Weller M., Linnebank M., Herrlinger U. “Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population”. 2010, Journal of Neurooncology, 100(2):187-92
  • Loeffler J, Ok M., Morton O., Mezger M., Einsele H. “Genetic Polymorphisms in the Cytokine and Chemokine System: Their Possible Importance in Allogeneic Stem Cell Transplantation”. 2010, Current  Topics in Microbiology and Immunology, 341: 83-96
  • Mezger M., Einsele H., Loeffler J. „Genetic susceptibility to infections with Aspergillus fumigatus“. 2010, Current Reviews in Microbiology, 36: 168-177
  • White L., Perry M., Loeffler J., Melchers W., Klingspor L., Bretagne S., McCulloch E., Cuenca-Estrella M., Finnstrom N., Donnelly P., Barnes R. on behalf of the European Aspergillus PCR Initiative.“Critical stages of extracting DNA from Aspergillus fumigatus in whole blood specimens“. 2010, Journal of Clinical Microbiology, 48: 3753-3756
  • McCormick A., Heesemann, L., Wagener J., Marcos V., Hartl D., Loeffler J., Heesemann J., Ebel F. „NETs formed by human neutrophils inhibit growth of the pathogenic mould Aspergillus fumigatus“. 2010, Microbes and Infection, 12(12-13): 928-36
  • Dannoui E., Schwarz P., Slany M., Loeffler J., Jorde A., Cuenca-Estrella M., Hasuer P., Shrief R., Huerre M., Freiberger T., Gaustrad P., Rodriguez-Tudela J., Bille J., Denning D., Bretagne S., Lortholary O. “Molecular detection and identification of Zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) fungal infection study group (EFISG) evaluation”. 2010, Journal of Clinical Microbiology 48: 2043-2046
  • Hebart H., Lengerke C., Ljungman P., Paya C., Klingebiel T., Loeffler J., Pfaffenrath S., Lewensohn-Fuchs I., Barkholt L., Tomiuk J., Meisner C., Lunenberg J., Top B., Razonable R., Patel R., Litzow M., Jahn G., Einsele H. “Prospective comparison of PCR-based versus late mRNA-based preemptive antiviral therapy for HCMV infection in patients after allo-SCT”. 2010, Bone Marrow Transplantation, 46(3):408-15
  • McCormick A., Loeffler J., Ebel F. “Aspergillus fumigatus: contours of a human fungal pathogen”. 2010, Cellular Microbiology, 11: 1535-1543
  • Loeffler J., Haddad Z., Bonin M. Romeike N., Mezger M., Schumacher, U., Kapp M., Gebhardt F., Grigoleit, G.U., Stevanović, S., Einsele, H., Hebart H. “Interaction Analyses of Human Monocytes Co-Cultured with Different Forms of Aspergillus fumigatus”. 2009, Journal of Medical Microbiology, 58: 49-58
  • Mengoli, C., Cruciani M,. Barnes R.A., Loeffler J., Donnelly, P.” A systematic review and meta-analysis of Polymerase chain Reaction for diagnosing invasive aspergillosis”. 2009, Lancet Infectious Diseases, 2: 89-96
  • Klingspor L. & Loeffler J. „Aspergillus PCR formidable challenges and progress“. 2009, Medical Mycology, 47: 241-247
  • Kapp M., Stevanović S., Fick K., Tan S.M., Loeffler J., Opitz A., Tonn T., Stuhler G. Einsele H., Grigoleit G.U. “CD8+ T-cell responses to tumor-associated antigens correlate with superior relapse-free-survival after allogeneic stem cell transplantation”. 2009, Bone Marrow Transplantation, 43: 399-410
  • Hebart H., Klingspor L., Klingebiel T., Loeffler J., Tollemar J., Ljungman P., Wandt H., Schaefer-Eckart K., Dornbusch H.J., Meisner C., Engel C., Stenger N., Mayer T., Ringden O., Einsele H. “A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT”. 2009, Bone Marrow Transplantation, 43: 553-561
  • Ok M., Latgé J.P., Baeuerlein C., Ebel F., Mezger M., Topp M., Kurzai O., Killian D., Kapp M., Grigoleit G.U., Sennefelder H., Arroyo J., Einsele H., Loeffler J. “Immune responses of human immature dendritic cells can be modulated by the recombinant Aspergillus fumigatus antigen Aspf1”. 2009, Clinical and Vaccine Immunology 16: 1485-1492
  • Mezger M., Bonin M., Kessler T., Gebhardt F., Einsele H., Loeffler J. “Toll Like receptor 3 has no critical role during early immune response of human monocyte-derived dendritic cells after infection with the human cytomegalovirus strain TB40E”. 2009, Viral Immunology 22: 343-351
  • Morton C., Loeffler J., de Luca, A., Frost S., Kenny C., Duval S., Romani L., Rogers T. “Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum”. 2009, Journal of Medical Microbiology, 59(Pt 4):408-13
  • Hornbach A., Heyken A., Schild L., Hube B., Loeffler J., Kurzai O. The glycosylphosphatidylinositol-anchored protease Sap9 modulated the interaction of Candida albicans with human neutrophils”. 2009, Infection and Immunity 77: 5216-5224
  • Gille C., Leiber A., Spring B., Kempf V.A., Loeffler J., Poets C.F., Orlikowsky T.W. “Diminished phagocytosis-induced cell death (PICD) in neonatal monocytes upon infection with Escherichia coli”. 2008, Pediatric Research 63: 33-38
  • Mezger M., Wozniok I., Blockhaus C., Kurzai O., Hebart H., Einsele H., Loeffler J. „Impact of Mycophenolic acid on the functionality of human polymorphnuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus”. 2008, Antimicrobial Agents and Chemotherapy, 52: 2644-2646
  • Storz K., Loeffler J., Koch, S., Vonthein R., Zouboulis C.C., Fresko I., Yazici H., Kötter I. “IL-6 receptor, IL-8 receptor and TNF-α238 (G/A) polymorphisms are not associated with Behcet`s disease in patients of German or Turkish origin. 2008, Clinical and Experimental Rheumatology 26: 52-55
  • Duval S., Donnelly P., Barnes R., Loeffler J. “PCR-based methods with aspergillosis as a model”. 2008, Journal of Invasive Fungal Infections, 2: 46-51
  • Mezger M., Steffens M., Beyer M., Manger C., Eberle J., Toliat M.R., Wienker T.F., Ljungman P., Hebart H., Dornbusch H.J., Einsele H., Loeffler J. “Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells”. 2008, Blood, 111: 534-536
  • Mezger M., Kneitz S., Wozniok I., Kurzai O., Einsele H., Loeffler J. “Pro-inflammatory response of human immature dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes”. 2008, Journal of Infectious Diseases, 197: 924-931
  • Staab A., Loeffler, J., Said H.M., Katzer A., Beyer M., Polat B., Einsele H., Flentje M., Vordermark D. “Modulation of glucose metabolism inhibits hypoxic accumulation of hypoxia-inducible fator-1α (HIF-1α)”. 2007, Strahlentherapie und Onkologie 183: 366-373
  • Staab A., Loeffler J., Said H.M., Diehlmann D., Katzer A., Beyer M., Fleischer M., Schwab F., Baier K., Einsele H., Flentje M., Vordermark D. “Effects of HIF-1 inhibition by chemotin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells”. 2007, BMC Cancer 7: 213
  • Wozniok I., Bach A., Schmitt C., Frosch M., Einsele H., Hube B., Loeffler J., Kurzai O. “Induktion of ERK-kinase signaling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils”. 2007, Cellular Microbiology, 10: 807-820
  • Lessing F., Kniemeyer O., Wozniok I., Loeffler J., Kurzai O., Haertl A., Brakhage A. “The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse model”. 2007, Eukaryotic Cell, 12: 2290-2302
  • Mezger M., Steffens M., Semmler C., Arlt E.M., Zimmer M., Kristjanson G.I., Wienker T.F., Toliat M.R., Kessler T., Einsele H., Loeffler J. “Investigation of Promotor Variations in DC-SIGN (CD209) and their relevance for human cytomegalovirus reactivation and disease after allogeneic stem cell transplantation. 2007, Clinical Microbiology and Infection, 14: 228-234
  • Loeffler J., Steffens M., Arlt E.M., Toliat M.R., Mezger M., Suk A., Wienker T.F., Hebart H., Nurnberg P., Boeckh M., Ljungman P., Trenschel R., Einsele H. “Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10 and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation”. 2006, Journal of Clinical Microbiology 44: 1847 – 1850
  • Gille C., Spring B., Tewes L., Loeffler J., Dannecker G.E., Hoffmann M.K., Eichner M., Poets C.F., Orlikowsky T.W. “Diminished response to Interleukin-10 and reduced antibody-dependent cellular cytotoxicity of cord blood monocyte-derived macrophages”. 2006, Pediatric Research 60: 153 – 158
  • Lengerke C., Ljubicic T., Meisner C., Loeffler J., Sinzger C., Einsele H., Hebart H. „Evaluation of the COBAS Amplicor HCMV Monitor for early detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation“. 2006, Bone Marrow Transplantation 38: 53-60
  • Bissinger A.L., Einsele H., Hamprecht K., Schumacher U., Kandolf R., Loeffler J., Aepinus C., Bock, T., Jahn G., Hebart H. “Infectious pulmonary complications after stem cell transplantation or chemotherapy: Diagnostic yield of bronchoalveolar lavage”. 2005, Diagnostic Microbiology and Infectious Diseases 52: 277 – 280
  • Kötter I., Daikeler T., Einsele H., Koch S., Lochmann L., Kanz L., Loeffler J. “Relapse of autoimmune diseases after autologous T cell depleted stem cell transplantation may be triggered by T cells recently emigrated from the thymus“. 2005, Annals of the Rheumatic Diseases 64: 1787 – 1789
  • Loeffler J., Dorn C., Hebart H., Cox P., Magga S., Einsele H. Development and evaluation of the Nuclisens Basic Kit NASBA for the detection of RNA from Candida species frequently resistant to antifungal drugs. 2003, Diagnostic Microbiology and Infectious Diseases, 45: 217-220
  • Loeffler J., Swatoch P., Akhawi-Araghi D., Hebart H., Einsele H. Automated RNA extraction by MagNAPure followed by rapid quantification of cytokine and chemokine gene expression with use of fluorescence resonance energy transfer. 2003, Clinical Chemistry, 49: 955-958
  • Kuci S., Wessels JT., Bühring HJ., Schilbach K., Schumm M., Seitz G., Löffler J., Bader P., Schlegel PG., Niethammer D., Handgretinger R. Identification of a novel class of human adherent CD34- stem cells that give rise to SCID-repopulating cells. 2003, Blood, 101: 869-876
  • Hebart H., Rauser G., Stevenovic S., Haenle C., Nussbaum A.K., Meisner C., Bissinger A.L., Tenzer S., Jahn G., Loeffler J., Rammensee H.G., Schild H., Einsele H. A CTL epitope from human cytomegalovirus IE1 defined by combining prediction of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation. 2003, Experimental Hematology 31: 966-973
  • Waidmann M., Bechtold O., Frick J.S., Lehr H.A., Schubert S., Dobrindt U., Löffler J., Bohn E., Autenrieth I.B. Bacteroides vulgatus protects against Escherichia coli induced colitis in gnotobiotic interleukin-2 deficient mice. 2003, Gastroenterology, 125: 162-177
  • Loeffler J., Kloepfer K., Hebart H., Najvar L., Graybill J.R., Kirkpatrick W.R., Patterson T.F., Dietz K., Bialek R., Einsele H. Polymerase chain reaction detection of Aspergillus-DNA in experimental models of invasive Aspergillosis. 2002, Journal of Infectious Diseases, 185: 1203-1206
  • Loeffler J., Schmidt K., Hebart H., Schumacher U., Einsele H. Automated extraction of genomic DNA from medically important yeast species and filamentous fungi by using the MagNAPure LC system. 2002, Journal of Clinical Microbiology, 40: 2240-2243
  • Loeffler J., Bauer R., Hebart H., Douek D.C., Rauser G., Bader P., Einsele H. Quantification of T-cell receptor excision circle DNA using fluorescence resonance energy transfer and the LightCycler system. 2002, Journal of Immunological Methods, 271: 167-175
  • Hebart H., Daginik S., Stevanovic S., Grigoleit U., Dobler A., Baur M., Rauser G., Sinzger C., Jahn G., Loeffler J., Kanz L., Rammensee H.G., Einsele H. Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-gamma-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation. 2002, Blood, 99: 3830-3837
  • Einsele H., Roosnek E., Rufer N., Sinzger C., Riegler S., Löffler J., Grigoleit U., Moris A., Rammensee H.G., Kanz L., Kleihauer A., Frank F., Jahn G., Hebart H. Infusion of Cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. 2002, Blood, 99: 3916-3922
  • Hebart H., Bollinger C., Fisch, P., Sarfati J., Meisner C., Baur M., Loeffler J., Monod M., Latge JP., Einsele H. Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematological malignancies. 2002, Blood, 100: 4521-4528
  • Hebart H., Rudolph T., Loeffler J., Middeldorp J., Ljubicic T., Jahn G., Einsele H. Evaluation of the Nuclisens CMV pp67 assay for detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation. 2002, Bone Marrow Transplantation, 30: 181-187
  • Von Müller L., Hampl W., Hinz J., Meisel H., Reip A., Engelmann E., Heilbronn R., Gärtner B., Krämer O., Einsele H., Hebart H., Ljubicic T., Löffler J., Mertens T. High variability between results of different in house tests for cytomegalovirus monitoring and a standardized quantitative plasma CMV PCR assay. 2002, Journal of Clinical Microbiology, 40: 2285-2287
  • Loeffler J., Hebart H., Cox P., Flues N., Schumacher U., Einsele H. Nucleic acid sequence-based amplification of Aspergillus RNA in blood samples. 2001, Journal of Clinical Microbiology, 39: 1626-1629
  • Hebart H., Brugger W., Grigoleit U., Gscheidle B., Loeffler J., Schäfer H.J.., Kanz L., Einsele H. Risk for Cytomegalovirus disease in patients receiving polymerase chain reaction-based preemptive antiviral therapy after allogeneic stem cell transplantation depends on transplantation modality. 2001, Correspondence to Blood, 97: 2183-2185
  • Hebart H., Wuchter P., Loeffler J., Gscheidle B., Hamprecht K., Sinzger C., Jahn G., Dietz K., Kanz L., Einsele H. Evaluation of the Murex CMV DNA Hybrid Capture assay (version 2.0) for early diagnosis of cytomegalovirus infection in recipients of an allogeneic stem cell transplant. 2001, Bone Marrow Transplantation, 28: 213-218
  • Rickerts V., Loeffler J., Böhme A., Einsele H., Just-Nübling G. Diagnosis of disseminated zygomycosis using a polymerase chain reaction assay. 2001, European Journal of Clinical Microbiology and Infectious Diseases, 20: 744-745
  • Loeffler J., Hagmeyer H., Hebart H., Henke H., Schumacher U., Einsele H. Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species. 2000, Clinical Chemistry, 46: 631-635
  • Einsele H., Hebart H., Kauffmann-Schneider C., Sinzger C., Jahn G., Bader P., Klingebiel T., Dietz K., Löffler J., Bokemeyer C., Müller C., Kanz L. Risk factors for treatment failures in patients receiving PCR-based preemptive therapy for CMV infection. 2000, Bone Marrow Transplantation, 25: 757-763
  • Loeffler J., Henke H., Hebart H., Schmidt D., Hagmeyer H., Schumacher U., Einsele H. Quantification of fungal DNA by using fluorescence resonance energy transfer and the LightCycler system. 2000, Journal of Clinical Microbiolgy, 38: 586-590
  • Loeffler J., Hebart H., Brauchle U., Schumacher U., Einsele H. Comparison between plasma and whole blood specimens for detection of Aspergillus DNA by PCR. 2000, Journal of Clinical Microbiology, 38: 3830-3833
  • Loeffler J., Hebart H., Magga S., Schmidt D., Klingspor L., Tollemar J., Schumacher U., Einsele H. Identification of rare Candida species and other yeasts by polymerase chain reaction and slot blot hybridization. 2000, Diagnostic Microbiology and Infectious Diseases, 38: 207-212
  • Hebart H., Löffler J., Reitze H., Engel A., Schumacher U., Klingebiel T., Bader P., Böhme A., Martin H., Bunjes D., Kern W.V., Kanz L., Einsele H. Prospective screening by a panfungal polymerase chain reaction assay in patients at risk for fungal infections: implications for the management of febrile neutropenia. 2000, British Journal of Haematology, 111: 635-640
  • Hebart H., Löffler J., Meisner C., Serey F., Schmidt D., Böhme A., Martin H., Engel A., Bunjes D., Kern W.V., Schumacher U., Kanz L., Einsele H. Early detection of Aspergillus infection after allogeneic stem cell transplantation by polymerase chain reaction screening. 2000, Journal of Infectious Diseases, 181: 1713-1719
  • Hebart H., Loeffler J., Kanz L., Einsele H. Molecular methods in the diagnosis of infections in the immunocompromised host. 2000, Current Opinion in Infectious Diseases, 13: 355-359
  • Loeffler J., Hebart H., Bialek R., Hagmeyer L., Schmidt D., Serey F.P., Hartmann M., Eucker J., Einsele H. Contaminations occuring in fungal PCR assays. 1999, Journal of Clinical Microbiology, 37: 1200-1202
  • Löffler J., Einsele H., Hebart H., Schumacher U., Hrastnik C., Daum G. Phospholipid and sterol analysis of plasma membranes of azole-resistant Candida albicans strains. 1999, FEMS Microbiology Letters, 185: 59-63
  • Loeffler J., Hagmeyer H., Hebart H., Henke H., Schumacher U., Einsele H. Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species. 2000, Clinical Chemistry, 46: 631-635
  • Kelly S.L., Lamb D.C., Loeffler J., Einsele H., Kelly D.E. The G464S amino acid substitution in Candida albicans sterol 14α-demethylase causes fluconazole resistance in the clinic through reduced affinity. 1999, Biochemical and Biophysical Research Communications, 262: 174-179
  • Loeffler J., Hebart H., Sepe S., Schumacher U., Klingebiel T., Einsele H. Detection of PCR-amplified fungal DNA by using a PCR-ELISA system. 1998, Medical Mycology, 36: 275-279
  • Hebart H., Löffler J., Jahn G., Einsele H. Reply to Kawasaki et al., „Cytomegalovirus monitoring by culture of urine and throat swabs from Japanese children undergoing autologous bone marrow or peripheral blood progenitor or allogeneic bone marrow transplantation“, Reply – JID A 970873. 1998, Journal of Infectious Diseases, 177: 519-520
  • Hebart H., Gamer D., Loeffler J., Müller C.A., Sinzger C., Jahn G., Bader P., Klingebiel T., Kanz L., Einsele H. Evaluation of Murex CMV DNA hybrid capture assay for detection and quantitation of cytomegalovirus infection in patients following allogeneic stem cell transplantation. 1998, Journal of Clinical Microbiology, 36: 1333-1337
  • Einsele H., Quabeck K., Müller K.D., Hebart H., Rothenhöfer I., Löffler J., Schaefer U.W. Prediction of invasive pulmonary aspergillosis from colonization of the lower respiratory tract before marrow transplantation. 1998, Letter to Lancet, 352: 1443
  • Löffler J., Kelly S.L., Hebart H., Schumacher U., Lass-Floerl C., Einsele H. Molecular analysis of CYP51 from fluconazole-resistant Candida albicans strains. 1997, FEMS Microbiology Letters, 151: 263-268
  • Löffler J., Hebart H., Schumacher U., Reitze H., Einsele H. Comparison of different methods for fungal DNA extraction from cultures and blood. 1997, Journal of Clinical Microbiology, 35: 3311-3312
  • Kelly S.L., Lamb D.C., Kelly D.E., Manning N.J., Loeffler J., Hebart H., Schumacher U., Einsele H. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6 desaturation. 1997, FEBS Letters, 400: 80-82
  • Hebart H., Schröder A., Löffler J., Klingebiel T., Martin H., Wassmann B., Gerneth F., Rabenau H., Jahn G., Kanz L., Müller C.A., Einsele H. Cytomegalovirus monitoring by polymerase chain reaction of whole blood samples from patients undergoing autologous bone marrow or peripheral blood progenitor cell transplantation. 1997, Journal of Infectious Diseases 175: 1490-1493
  • Einsele H., Hebart H., Roller G., Löffler J., Rothenhöfer I., Müller C.A., Bowden R.A., van Burik J.A., Engelhard D., Kanz L., Schumacher U. Detection and identification of fungal pathogens in blood by using molecular probes. 1997, Journal of Clinical Microbiology, 35: 1353-1360
  • Löffler J., Schumacher U., Hebart H., Reitze H., Einsele H. Extraction of fungal DNA from cultures and blood using the QIAamp Tissue Kit. 1996, Qiagen News, 4/96: 16-17
  • Hebart H., Müller C.A., Löffler J., Jahn G., Einsele H. Monitoring of CMV infection: a comparison of PCR from whole blood, plasma-PCR, pp65 antigenemia and virus culture in patients after bone marrow transplantation. 1996, Bone Marrow Transplantation, 17: 861-868
  • Kelly S.L., Lamb D.C., Kelly D.E., Loeffler J., Einsele H. Resistance to fluconazole and amphotericin B in Candida albicans from AIDS patients. 1996, Letter to Lancet, 348: 1523-1524
  • Einsele H., Ehninger G., Hebart H., Wittkowski K.M., Schuler U., Jahn G., Mackes P., Herter M., Klingebiel T., Löffler J., Wagner S., Müller C.A. Polymerase chain reaction reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation. 1995, Blood, 86: 2815-2820